Well, here ends my 16th play through.
Sniper Rifles are more fun than I thought they'd be, especially the OP ones TMM mentioned. I do want to do a Sentinel play through just so I can say I've done all of the classes. But as fun as Engineer and Infiltrator was, I think I'll always prefer Vanguard.
All three Maleshep play throughs have been Talimances. I've honestly come to prefer her over Liara, though I typically prefer Femshep...so...yeah.
Now that I've finally gone through a play through with Kaiden, I think I can say with confidence that I absolutely prefer Ashley. Sure she's a bitch up until after the Cerberus coup in 3, but she does grow and her love of her family and how she's there for her sister in 3 makes her far more interesting than Kaiden was. He honestly had nothing to even make me think of even the possibility of saving him again in the future. He's just...boring.
Also, for the second time, I got The Illusive Man to off himself. I must have finally figured it out.