Saw an interview where he said that there won't be a Deadpool 4. So I guess if we do see him again, it will be in the MCU.
As awesome as the movie is, and as much money as it's already earned, Ryan and company was having to fight Bob Igor every step of the way. Like even now there's talk about them butting heads on what should make it into thefreaking DIRECTOR'S cut. You know, director's cut? The cut of the film that adds things the director wanted but couldn't get into the theatrical cut so they put in in the director's cut? They're having to fight for that!
As much as this may be a passion project for Ryan in particular, I really couldn't blame him if he didn't want to touch it again.
Don't get me wrong, I love this movie. I love it so much it was the one movie this summer that could get my butt in the theater. I can't wait until I can see the extended cut on Bluray.
But I love it for Ryan Reynolds and his team. Bob and his whole company can sit and spin.